成员介绍

凌雪萍

     副教授
     硕士生导师
     电话：
     Email:xpling@xmu.edu.cn

个人简历

· 2017.08-至今, 厦门大学化学化工学院, 副教授

· 2007.07-2017.08, 厦门大学化学化工学院, 助理教授

· 2013.03-2014.03, 美国宾州州立大学访问学者

· 2005.09-2011.06, 厦门大学化学生物学专业, 研究生/博士

· 2000.09-2003.06 , 天津商业大学发酵工程专业, 研究生/硕士

· 1996.09-2000.06, 天津商业大学食品科学与工程专业, 本科/学士

研究方向

· 高值生物基产品关键制备技术的研究与开发

· 酶的高效表达体系构建及其新型功能脂质的开发应用

· 益生菌的高密度发酵及其功能性研究

教学工作

· 《生物化学A》、《分子生物学》、《生物化学基础实验》

承担的课题

1) 国家自然科学基金(22478324), 磷脂：二酰甘油酰基转移酶（PDAT）在裂殖壶菌DHA-甘油三酯合成中的催化功能与分子机制.

2) 厦门市科技计划自然科学基金(3502Z20227183), GPC酰基化途径调控裂殖壶菌合成 DHA-甘油三酯的分子机制.

3) 国家重点研发计划(2022YFC2104600), 低廉生物质制备全生物基可降解包装材料关键技术（生物基单体及聚乳酸合成关键技术）.

4) 福建省基金(2017J01077), 结合基因敲除和同源基因重组研究关键基因对裂殖壶菌合成DHA的影响机制.

5) 国家自然科学基金(31871779), 裂殖壶菌利用聚酮合成酶（Polyketide synthase, PKS）途径合成二十碳五烯酸代谢机制.

6) 国家重点研发计划重点专项(2016YFD0400205), 新型食品加工技术对特征组分结构修饰与品质功能调控机理.

7) 厦门市科技计划项目(3502Z20153005), 高密度发酵高山被孢霉生产微生物来源花生四烯酸（ARA）.

8) 国家自然科学基金(41206115), 利用基因敲除技术结合蛋白质组学分析裂殖壶菌产DHA的氮源调控分子机制.

9) 福建省基金(2013J01060), 应用蛋白质组学技术解析裂殖壶菌产DHA的氮源调控,2013.01-2015.12.

10) 厦门市海洋局, 海洋微藻生产生物活性虾青素关键技术研究和示范应用.

11) 国家自然科学基金(31071488), 应用蛋白质组学技术解析虾青素引起的免疫调节分子机制.

12) 福建省科技厅重大专项(2010NZ0001-4), 微藻提取DHA的技术开发.

13) 企业项目, DMBR出水的水质脱色技术开发, 四川优异环境科技有限公司.

14) 企业项目, 新一代益生菌的产业化研究.

近期主要代表论著

1. Shaofeng Chen^#, Weide Xiong^#, Xueping Ling*. Improved performance of toxic Streptomyces phospholipase D expression by combinatorial optimization in the trehalase-deficient Escherichia coli using CRISPR-Cas9 knockout. Biochemical Engineering Journal, 2025, 215:109640.

2. Haoyi Yang, Xiaoyu Lin, Xueping Ling*, Ning He*. Current status and advances in the green synthesis of muconic acid, Critical Reviews in Biotechnology, 2024, https://doi.org/10.1080/07388551.2024.2433998.

3. Yiting Zhang, Xuejun Wu, Xueping Ling*. Functions of aldolase in lipid synthesis of Schizochytrium sp. by gene disruption to switch carbon metabolism, Blue Biotechnology, 2024, 1:17.

4. Yiting Zhang^#, Xiaowen Cui^#, Xihuang Lin*, Xueping Ling*. Knockout of a PLD gene in Schizochytrium limacinum SR21 enhances docosahexaenoic acid accumulation by modulation of the phospholipid profile, Biotechnology for Biofuels and Bioproducts, 2024, 17(1):16.

5. Haiting Wu^#, Shuhua Qi^#, Xueping Ling*. Strategies for high cell-density cultivation of Akkermansia muciniphila and its potential metabolism, Microbiology Spectrum, 2023, e02386-23.

6. Liwen Shu^#, Xin Zheng^#, Xueping Ling*. Transesterification of phosphatidylcholine with DHA-rich algal oil using immobilized Candida antarctica lipase B to produce DHA-phosphatidylcholine, Enzyme and Microbial Technology, 2023, 110266.

7. Qinghua Yang, Zhenyu Xie, Xueping Ling*. Genetic regulation and fermentation strategy for squalene production in Schizochytrium sp., Applied Microbiology and Biotechnology, 2022, 106: 2415-2431.

8. Shaofeng Chen^#, Weide Xiong^#, Xueping Ling*. Study on the mechanism of efficient extracellular expression of toxic streptomyces phospholipase D in Brevibacillus choshinensis under Mg²⁺ stress, Microbial Cell Factories, 2022, 21:41.

9. Rongrong Ma#, Huipeng Liu#, Xueping Ling*, Yinghua Lu*. Effects of high hydrostatic pressure treatment: characterization of eel (Anguilla japonica) surimi, structure and angiotensin-converting enzyme inhibitory activity of myofibrillar protein, Food and Bioprocess Technology, 2021, 14: 1631–1639.

10. Qinghua Yang, Tao Lu, Xueping Ling*. Regulation of polyunsaturated fatty acids synthesis by enhancing carotenoid-mediated endogenous antioxidant capacity in Schizochytrium sp., Algal Research, 2021, 55: 102238.

11. Xueshan Pan, Baobei Wang, Xueping Ling*, Yinghua Lu*. Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by phytohormone with metabolite biosynthesis and gene expression profiles, Microbial Biotechnology, 2020, 13, 1446-1460.

12. Xueping Ling*, Hao Zhou, Yinghua Lu*. Functions of enyolreductase (ER) domains of PKS cluster in lipid synthesis and enhancement of PUFAs accumulation in Schizochytrium limacinum SR21 using triclosan as a regulator of ER, Microorganisms, 2020, 8:300.

13. Di Pan, Biling Tang, Xueping Ling*, Yuanpeng Wang*. Effect of high hydrostatic pressure (HHP) processing on immunoreactivity and spatial structure of peanut major allergen Ara h 1, Food and Bioprocess Technology, 2020, 13:132-144.

14. Weide Xiong, Weiyi Luo, Xueping Ling*, Yinghua Lu*. High expression of toxic Streptomyces phospholipase D in Escherichia coli under salt stress and its mechanism, AIChE Journal, 2019, 66(4): e16856.

15. Jun Li, Hao Zhou, Xueping Ling*. The role of fluconazole in the regulation of fatty acid and unsaponifiable matter biosynthesis in Schizochytrium sp. MYA 1381, BMC Microbiology, 2019, 19: 256.