刘文
博士生导师
电话：0592-2881146
Email:w2liu@xmu.edu.cn
个人简历
刘文博士、闽江学者特聘教授。2001年毕业于厦门大学生物学系，获生物学学士学位；2002年至2005年工作于美国Sanford-Burnham医学研究所； 2011年毕业于美国加州大学圣地亚哥分校生物学系，获生物学博士学位；2011年4月至 2013年4月在美国加州大学圣地亚哥分校医学院从事博士后研究；2013年5月至9月在美国加州大学圣地亚哥分校医学院担任助理项目科学家；2013年9月至今任厦门大学药学院教授。主要从事表观遗传学调控子的分子作用机制及其在癌症等重大疾病发生发展中的应用研究，同时也致力于发现癌症特异性的非编码RNA及其分子作用机制的研究，并探寻能够有效和特异作用于表观遗传学调控子和非编码RNA的活性小分子。论文发表在Nature，Cell, Cancer Cell，Molecular Cell, PNAS等科学期刊。研究成果获得两项美国专利。研究获得HUANG MEM SC FND 奖学金（加州大学）, Susan G. Komen for the Cure奖学金以及国家自然基金的支持。
研究方向
本实验室主要开展以下研究内容：去甲基化酶在细胞周期调控，基因转录和剪接以及癌症发生和发展中的分子作用机制；筛选，合成和优化能特异而有效抑制表观遗传学调控子的活性小分子，以期达到预防，治疗癌症等重大疾病；大规模筛选组蛋白修饰酶，特别是甲基化和去甲基化酶的非组蛋白底物；深化非编码RNA的分子机制及功能研究。
近期主要代表论著:
Liu W*, Ma Q, Wong K.K., Li W.B., Ohgi K.A., Zhang J., Aggarwal. A., Rosenfeld, M.G*. Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release. Cell (Cell 2013 Dec 19; 155(7):1581-1595) (*Co-corresponding author,共同通讯作者).
Liu W, Tanasa B, Tyurina O.V., Zhou T.Y., Gassmann R, Liu W.T., Ohgi K.A., Benner C, Garcia-Bassets I, Aggarwal A.K., Desai A, Dorrestein P.C., Glass C.K., Rosenfeld M.G. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 2010 Jul 22; 466(7305):508-12
Zhou Hu*,Liu W*, Su Y, Wei Z, Liu J, Kolluri S.K., Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li W.G., Lin B, Zhang H.P., Yu J, Luo S.P., Zeng J.Z., Duester G, Huang P.Q., Zhang X.K. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell 2010 Jun 15;17(6):560-73 (*Co-first author,共同第一作者).
Yang L* , Lin C*,Liu W, Zhang J, Ohgi K.A., Grinstein J.D, Dorrestein P.C., Rosenfeld M.G. ncRNA- and Pc2 Methylation-dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs. Cell 2011 Nov 11; 147(4):773-88 (*Co-first author,共同第一作者).
Cao, X.,Liu, W.,, Ling, F., Li, H., Kolluri S.K., Lin, B., Han, Y.H., Dawson, M.I., and Zhang, X.K. Retinoid X receptor regulates Nur77/TR3 dependent apoptosis by modulating its nuclear export and mitochondrial targeting. Molecular and Cellular Biology 24, 9705-9725 (2004).
Zhang L,Liu. W, Szumlinski KK, Lew J. p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity. Proceedings of the National Academy of Sciences Dec 4; 109 (49):20041-6. (2012)
Zhou Z.H., Qiu, J.S.,Liu W, Zhou Y, Plocinik, M.R., Li, H.R., Hu, Q.D., Ghosh, G, Adams, J.A., Rosenfeld, M.G., Fu, X.D. The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus. Molecular Cell 2012 Aug 10; 47(1-12).
Stender J.D., Pascual G,Liu W, Kaikkonen M.U., Do K, Spann N, Boutros M, Perrimon N, Rosenfeld M.G., Glass C.K. Control of Pro-Inflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20. Molecular Cell 48, 1�11, October 12, 2012.
Lin, B., Kolluri, S.K., Lin, F.,Liu, W.,, Han, Y.H., Cao, X., Dawson, M.I., Reed, J.C., Zhang, X.K. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116, 527-540 (2004).
Zhang S.S., Hao E, Yu J,Liu W, Wang J, Levine F, Feng G.S. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proceedings of the National Academy of Sciences 2009 May 5; 106(18):7531-6.
Zhu HH, Ji K, Alderson N, He Z, Li S,Liu W, Zhang DE, Li L, Feng GS. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 2011 May 19; 117 (20):5350-61.
Kolluri S.K., Corr M., James, S.Y., Bernasconi M., Lu, D.S.,Liu, W.,, Cottam H.B., Leoni L.M., Carson D.A., Zhang X.K. The R-enantiomer of the nonsteroidal anti-inflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proceedings of the National Academy of Sciences 102, 2525-2530 (2005).
Wang D, Garcia-Bassets I, Benner C, Li W, Su X, Zhou Y, Qiu J,Liu W, Kaikkonen MU, Ohgi KA, Glass CK, Rosenfeld MG, Fu XD. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 2011 May 15; 474(7351):390-4.
Zeng, J.Z., Sun, D.F., Wang, L., Cao, X.H., Qi, J.B., Yang, T., Hu, C.Q.,Liu, W.,, and Zhang, X.K. Hypericum sampsonii Induces Apoptosis and Nuclear Export of Retinoid X Receptor-alpha. Carcinogenesis 2006 Oct;27(10):1991-2000
Bingzhen Lin, Siva Kumar Kolluri, Feng Lin,Wen Liu, Young-Hoon Han, Xihua Cao, Marcia I. Dawson, John C. Reed, and Xiao-Kun Zhang. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor TR3. AACR Meeting Abstracts 2004: 1114-b.
Michael Geoffrey Rosenfeld, Liuqing Yang, Chunru Lin,Wen Liu, Esperanza Nunez, Wenbo Li and qidong hu. ncRNAs, Subnuclear Architecture, and Relocation of Regulated Transcription Units: A Strategy for Controlling Regulated Gene Programs in the Three Dimensional Space of the Nucleus. The FASEB Journal 2012;26:333.5