个人简历

2021-     厦门大学化学化工学院，教授、博导、课题组长

2018-2021 美国伊利诺伊大学香槟分校，研究员（Research Scientist，合作导师：赵惠民教授）

2017-2021 美国ESTose Biorenewables初创公司，联合创始人、研发主任

2013-2018 美国爱荷华州立大学，博士后（合作导师：邵增怡教授）

2011-2013 中科院天津工业生物技术研究所,  助理研究员（合作导师：孙际宾研究员）

2006-2011 南开大学，博士（导师：宋存江教授、李后魂教授）

2002-2006 烟台大学，本科（导师：王敏强教授）

目前学术兼职：Biotechnology Reports主编，Biotechnology for Biofuels, Microbial Cell Factories, Journal of Applied Microbiology, BMC Microbiology, BMC Biotechnology等杂志副主编；智利国家科学技术发展基金（FONDECYT）评审专家。

研究方向

合成生物学，代谢工程，基因编辑，酶工程

承担的课题:

1.  Center for Advanced Biofuels and Bioproducts Innovation (DE-SC0018420)，DOE，$115M, 2018-2022 （参与）

2.  Exploring nucleosome-depleted sequences for novel applications in synthetic biology (1749782), NSF Career Award, $551K, 2018-2023 （参与）

3.  Unraveling core design principles to explore the world of nonconventional yeasts (1716837), NSF, $600K, 2017-2020 （参与）

4.  Designing fatty acid sensors for high throughput product profiling, Industry Seed Fund, $100K, 2014-2016 （参与）

5.  门多萨假单胞菌NK-01合成褐藻寡糖和中长链聚羟基脂肪酸酯的代谢途径改造, 国家自然基金面上, 33万, 2011-2013 （参与）

近期主要代表论著:

1.  C. Lopez, M. Cao*, Z. Yao, Z. Shao*. Revisiting the unique structure of autonomously replicating sequences in Yarrowia lipolytica and its role in pathway engineering. Applied Microbiology and Biotechnology, 2021, https://doi.org/10.1007/s00253-021-11399-4

2.  T. Wang*, B. Si, Z. Gong, Y. Zhai, M. Cao*, C. Peng. Co-hydrothermal carbonization of food waste-woody biomass blend: interaction effects on the hydrochar properties and nutrients characteristics. Bioresource Technology, 2020, 316: 123900

3.  M. Cao^#, V. Tran^#, H. Zhao. Unlocking nature’s biosynthetic potential by directed genome evolution. Current Opinion in Biotechnology, 2020, 66: 95-104

4.  Y. Zhao,Z. Yao,D. Ploessl,M. Monti, D. Schindler, M. Gao, Y. Cai, M. Qiao, C. Yang*, M. Cao*, Z. Shao*. Leveraging the Hermes transposon to accelerate the development of nonconventional yeast-based microbial cell factories. ACS Synthetic Biology, 2020, 9(7): 1736-1752

5.  M. Cao^#, Z. Fatma^#, X. Song, P. Hsieh, V. Tran, W. Lyon, M. Sayadi, Z. Shao, Y. Yoshikuni, H. Zhao. A genetic toolbox for metabolic engineering of Issatchenkia orientalis. Metabolic Engineering, 2020, 59: 87-97

6.  M. Cao^#, M. Gao^#, M. Suástegui, Y. Mei, Z. Shao. Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products. Metabolic Engineering. 2020, 58: 94-132

7.  J. Lian^#, C. Schultz^#, M. Cao^#, M. HamediRad^#, H. Zhao. Multi-functional genome-wide CRISPR system for high throughput genotype-phenotype mapping, Nature Communications. 2019, 10:5794

8.  V. Tran^#, M. Cao^#, Z. Fatma, X. Song, H. Zhao. Development of a CRISPR/Cas9-based tool for gene deletion in Issatchenkia orientalis. mSphere. 2019, 4(3): e00345-19

9.  M. Cao, M. Gao, D. Ploessl, Z. Shao. CRISPR-mediated genome editing and gene repression in Scheffersomyces stipitis. Biotechnology Journal.2018, 13, 1700598

10. M. Cao^#, J. Feng^#, S. Sirisansaneeyakul, C. Song, Y. Chisti. Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid. Biotechnology Advances, 2018, 36: 1424-1433

11. M. Cao, A. Seetharam, A. Severin, Z. Shao. Rapid isolation of centromeres from Scheffersomyces stipitis. ACS Synthetic Biology, 2017, 6(11), 2028-2034

12. M. Cao, M. Gao, C. Lopez-Garcia, Y. Wu, A. Seetharam, A. Severin, Z. Shao. Centromeric DNA facilitates nonconventional yeast genetic engineering. ACS Synthetic Biology, 2017, 6(8): 1545-1553

13. D. Ploessl, Y. Zhao, M. Cao, S. Ghosh, C Lopez-Garcia, M. Sayadi, S Chudalayandi, A. Severin, L. Huang, M. Gustafson, Z. Shao. A repackaged CRISPR platform unlocks the utility of non-homologous end joining in microbial factory engineering. Nature Chemical Biology. 2021, Accepted

14. Y. Wang^#, P. Xue^#, M. Cao, T. Yu, S. Lane, H. Zhao. Directed Evolution: Methodologies and Applications. Chemical Reviews. 2021, https://doi.org/10.1021/acs.chemrev.1c00260

15. J. Feng, J. Zhang, Y. Ma, Y. Feng, S. Wang, N. Guo, H. Wang, P. Wang, P. Jiménez-Bonilla, Y. Gu, J. Zhou, Z. Zhang, M. Cao, D. Jiang, S. Wang, X. Liu, Z. Shao, I. Borovok, H. Huang, Y. Wang. Renewable fatty acid ester production in Clostridium. Nature Communications. 2021, 12:4368

授权专利：

1.   H. Zhao, M. Cao, V. Tran, Z. Fatma, A genetic toolbox for metabolic engineering of nonconventional yeast. US Patent, 2020, 17/180,741

2.   Z. Shao, M. Cao, M. Suastegui, M. Gao. Methods and compositions for production of aromatic and other compounds in yeast. US Patent, 2019, 16/019,822

3.   宋存江，李保宾，王淑芳，李强，耿伟涛，曹名锋等，一株具有解磷作用的枯草芽孢杆菌及其应用，国际/中国发明专利，2012, WO 2012058835/CN102061273

4.   王淑芳，胡玉彬，洪彦航，曹名锋等，一种聚谷氨酸水凝胶的制备方法，中国发明专利，2011，CN101891954.

5.    宋存江，杜阳，曹名锋等，一株γ-聚谷氨酸合成菌及其发酵方法，中国发明专利，2011，CN102206597

6.   宋存江，苏文萍，曹名锋等，一株葡糖醋杆菌及其应用，中国发明专利，2009，CN101591626

7.   宋存江，郭文斌，王淑芳，曹名锋等，门多萨假单胞菌NK-01用于生产褐藻寡糖的用途和方法，中国发明专利，2009，CN101555505

8.   宋存江，刘莉，王淑芳，曹名锋等，一株谷氨酸非依赖型γ-聚谷氨酸合成菌及其发酵方法，中国发明专利，2008，CN101508962

获奖情况：

2021 厦门大学南强青年拔尖人才支持计划（A类）