何宁
博士生导师
电话:0592-2185495,15980836109
Email:hening@xmu.edu.cn
个人简历
2019年9月-2020年3月:美国纽约州立大学宾汉顿分校,高级研究学者
2014年12月-2016年1月:美国纽约州立大学宾汉顿分校,访问学者
2011年8月-今:厦门大学化学化工学院,教授,博士生导师
2005年11月-2006年11月:德国明斯特大学分子微生物与生物技术研究所,博士后
2005年9月-2011年7月:厦门大学化学化工学院,副教授
2002年8月-2005年8月:厦门大学化学化工学院,讲师
1999年2月-2002年7月:江南大学生物工程学院,发酵工程专业,博士
承担的课题:
近期主要代表论著:
研究方向
细菌胞外聚合物合成过程与代谢调控机制
多不饱和脂肪酸发酵技术与菌株代谢工程
植物多糖分离纯化与功能性食品开发
超高压技术在食品加工中的应用及其对蛋白/果胶分子结构与功能影响机制
微生态制剂与新型饲料研发
教学工作
本科课程(化学工程/生物工程专业):生物工艺学、生物化学、专业实验
硕士研究生:高等生物工程、生物化学、微生物学、工业微生物代谢调控
博士研究生:化工与生工前沿、高等生物工程
国际研究生:环境生物技术
承担的课题:
(1)国家自然科学基金(31871779),裂殖壶菌利用聚酮合成酶途径合成二十碳五烯酸代谢机制
(2)国家自然科学基金面上项目(21676221),地衣芽孢杆菌胞外聚合物合成的调控机制研究
(3)南方海洋研究中心项目(15GYY024NF03),利用代谢工程改造海洋微生物制备二十碳五烯酸EPA
(4)国家重点研发计划专项课题(2016YFD0400205),食品加工过程中组分结构变化与品质调控机制
(5)教育部新世纪优秀人才(NCET-13-0501)
(6)福建省高校产学合作计划项目(2015H6004),新型食品级絮凝剂——聚谷氨酸的研发,
(7)国家自然科学基金面上项目(51378444),关键基因对微生物胶体稳定性的影响机制与细菌细胞的絮凝行为调控
(8)973项目(2013CB733505),副产物无害化与资源化的减排技术及评价
(9)厦门市科技计划对台合作项目(3502Z20121021),地衣芽孢杆菌絮凝基因探索及其生物絮凝剂高产菌株构建
(10)国家科技支撑计划项目(2011BAE16B03),制糖生化助剂开发及应用
(11)福建省发改委产业技术开发项目([2010]983号),复合微生物发酵豆粕关键技术及其产业化
(12)科研院所技术开发研究专项资金(2009EG111023),制糖生物絮凝剂的开发及其应用
(13)教育部留学回国人员基金,生物絮凝剂工程菌株的构建
(14)厦门市科技计划项目(3502Z20093006),生物絮凝剂的过量合成与中试生产
(15)福建省科技重点项目(2008Y0060)剩余污泥资源化生产可降解塑料——聚羟基烷酸PHAs
(16)国家自然科学基金青年基金(30700020),生物絮凝剂高产工程菌株的构建与表达
(17)科技型中小企业技术创新基金(09C26213504319),利用非粮作物蕉芋生产燃料乙醇
近期主要代表论著:
(1) Zhen Chen, Zhi Wang, Hongyu Yuan, Ning He*. From tea Leaves tofactories: a review of research progress in l-theanine biosynthesis and production, J. Agric. Food Chem. 2021, 69, 1187-1196
(2) Huipeng Liu, Yuanhong Li, Biling Tang, Yajuan Peng, Xuee Wu, Liming Che, SiewYoung Quek, Ning He*. Effects of xylooligosaccharide on angiotensin Iconverting enzyme inhibitory activity of fish actomyosin and quality of snakehead balls with or without high hydrostatic pressure treatment, LWT - Food Science and Technology, 2020, 140:1-9
(3) Yiming Wang, Jinjin Zeng, Lingwei Wang, Yuanmin Yuan, Qingbiao Li, Jianning He, Ling Lin, Ning He*. Eco-friendly and durable PCPS nanoparticles for the effective separation of oil-water emulsions, Nanoscale, 2020, 12, 11489-11496
(4) Zhipeng Li, Xueping Ling, Hao Zhou, Tong Meng, Jinjin Zeng, Wei Hang, Yanyan Shi, Ning He*. Screening chemical modulators of benzoic acid derivatives to improve lipid accumulation in Schizochytrium limacinum SR21 with metabolomics analysis, Biotechnology for Biofuels, 2019,12:209-220
(5) Zhenglong Li#, HuipengLiu#, RongrongMa, BilingTang, Di Pan, YajuanPeng, XuepingLing, Yuanpeng Wang, Xuee Wu, Liming Che, Ning He*. Changes in Tropomyosin Structure Alter Angiotensin-converting Enzyme Inhibitory Activity and Texture Profiles of Eel Ball under High Hydrostatic Pressure, Food & Function, 2018, 9, 6535 - 6543
(6) Xi Chen; Zhipeng Li; Yuanpeng Wang, Yinghua Lu, Qingbiao Li*, Ning He*. Nitrogen and phosphorus removal from anaerobically digested wastewater by microalgae cultured in a novel membrane photobioreactor, Biotechnology for Biofuels, 2018, 11: 190-201
(7) Zhipeng Li, Xi Chen, Jun Li, Xueping Ling, Ning He*. Functions of PKS genes in lipid synthesis of Schizochytrium sp. by gene disruption and metabolomics analysis, Marine biotechnology, 2018,9:1-11.
(8) Zhipeng Li, Zhen Chen, Yuanpeng Wang, Qingbiao Li, Ning He*. Anaerobic co-digestion of sewage sludge and food waste for hydrogen and VFA production with microbial community analysis. Waste management,2018,78:789-799
(9) Zhipeng Li, Tong Meng, Xueping Ling, Jun Li, Chuqiang Zheng, Yanyan Shi, Zhen Chen, Zhenqi Li, Qingbiao Li, Yinghua Lu, and Ning He*. Overexpression of Malonyl-CoA: ACP Transacylase in Schizochytrium sp. to Improve Polyunsaturated Fatty Acid Production, Journal of Agricultural and Food Chemistry, 2018, 66(21):5382-5391
(10) Peize Liu, Zhen Chen, Lijie Yang, Qingbiao Li, Ning He*. Increasing the bioflocculant production and identifying the effect of overexpressing epsB on the synthesis of polysaccharide and γ-PGA in Bacillus licheniformis, Microbiol Cell Factory, 2017,16:163-172
(11) Zhi Wang, Zhen Chen, Lijie Yang, Fen Tan, Yuanpeng Wang, Qingbiao Li, You-Im Chang, Chuan-jian Zhong, and Ning He*, Effect of surface physicochemical properties on flocculation behavior of Bacillus licheniformis, RSC advances, 2017,7:16049-16056
(12) Wencheng Yu, Zhen Chen, Hong Ye, Peize Liu, Zhipeng Li, Yuanpeng Wang, Qingbiao Li, Ning He*, Effect of glucose on poly-gamma-glutamic acid metabolism in Bacillus licheniformis, Microbiol Cell Factory, 2017, 16:22-28
(13) Zhen Chen, Tong Meng, Zhipeng Li, Peize Liu, Yuanpeng Wang, Ning He*, Dafeng Liang*.Characterization of a beta-glucosidase from Bacillus licheniformis and its effect on bioflocculant degradation. AMB Express, 2017, 7:197-203
(14) Zhen Chen, Zhipeng Li, Peize Liu, Yu Liu, Yuanpeng Wang, Qingbiao Li, Ning He*. Characterization of a novel bioflocculant from a marine bacterium and its application in dye wastewater treatment, BMC Biotechnology, 2017,17:84-94
(15) Bing Liu, Chaogang Wang, Danxia Liu, Ning He*, Xu Deng*. Hg tolerance and biouptake of an isolated pigmentation yeast Rhodotorula mucilaginosa. Plos ONE, 2017,3(2):1-14
(16) Wencheng Yu, Zhen Chen, Liang Shen, Yuanpeng Wang, Qingbiao Li, Shan Yan, Chuan-Jian Zhong, Ning He*, Proteomic profiling of Bacillus licheniformis reveals a stress response mechanism in the synthesis of extracellular polymeric flocculants, Biotechnology and Bioengineering, 2016, 113(4):797-806
(17) Zhen Chen, Peize Liu, Zhipeng Li, Wencheng Yu, Zhi Wang, Haosheng Yao, Yuanpeng Wang, Qingbiao Li, Xu Deng, Ning He*, Identification of key genes involved in polysaccharide biofloculant synthesis in Bacillus licheniformis, Biotechnology and Bioengineering, 2017, 114(3):645
(18) Li H, Tan F, Ke LT, Xia D, Wang YP, He N, Zheng YM, Li QB, Mass balances and distributions of C, N, and P in the anaerobic digestion of different substrates and relationships between products and substrates, Chemical Engineering Journal, 2016, 287:329-336
(19) Ndikubwimana T, Zeng X, Murwanashyaka T, Manirafasha E, He N, Shao W, Lu Y, Harvesting of freshwater microalgae with microbial bioflocculant: a pilot-scale study, Biotechnology for biofuels, 2016, 9(1): 47-57
(20)任洪强,耿金菊,何宁。发酵生态工程,化学工业出版社,2012.5
授权发明专利
(1)从诺卡氏菌制备的一种生物絮凝剂,ZL 01 1 08045.0
(2)生物絮凝剂XM-11的发酵过程分阶段供氧的控制方法,ZL 200710009605.7
(3)从重组大肠杆菌XM-LU制备内切-β-1,3-1,4-葡聚糖酶的方法, ZL200810070684.7
(4)利用地衣芽孢杆菌制备生物絮凝剂的方法,ZL200910111262.4
(5)地衣芽孢杆菌合成的生物絮凝剂在制糖中的应用,ZL 201010269454.0
(6)一种3-羟基丁酸和3-羟基戊酸共聚物的合成方法,ZL201210167714.2
(7)一种以剩余污泥发酵液为底物合成聚羟基脂肪酸酯的方法,ZL201110394695.2
(8)利用地衣芽孢杆菌制备γ-聚谷氨酸生物絮凝剂的方法,ZL201310112328.8
(9)利用地衣芽孢杆菌同时合成两种不同成分生物絮凝剂的方法,ZL201410148579.6
(10)利用海洋交替单胞菌制备生物絮凝剂的方法,ZL201510180905.6
(11)过表达尿苷二磷酸葡萄糖焦磷酸化酶基因的工程菌及构建,ZL201610028141.3
(12)产多糖絮凝剂的地衣芽孢杆菌基因工程菌及其构建方法,ZL201610028296.7
(13)一种脱氢异构酶基因敲除的裂殖壶菌工程菌的构建方法及其应用,ZL 2017 1 0077962.0
(14)一种酮基合成酶基因敲除的裂殖壶菌工程菌的构建方法及其应用,专利2017 1 0078025.7
国际发明专利
(1)Methods for simultaneously synthesizing a biological flocculant with two different components by using Bacillus licheniformis, US 10,584,362
(2)Membrane photobioreactor used for treating excessive nitrogen and phosphorus in biogas slurry and its treatment method,US 10,533,148
(3)Method for preparing eel surimi by high pressure and CO₂ combined with enzyme treatment,BE2018/5692
获奖
(1)生物絮凝剂的高效生产与应用,2014年度中国石油和化学工业联合会,技术发明奖,三等奖
(2)绿色制糖关键技术开发及应用,2019年中国轻工业联合会,科学技术进步奖,一等奖