成员介绍

凌雪萍

副教授
硕士生导师
电话：0592-2186038
Email:xpling@xmu.edu.cn

个人简历

2005.09-2011.06, 厦门大学化学系化学生物学专业，研究生/博士

2000.09-2003.06 , 天津商业大学生物工程系发酵工程专业, 研究生/硕士

1996.09-2000.06, 天津商业大学食品工程系食品科学与工程专业,本科/学士

研究方向

微生物代谢产物的调控网络

微生物产油机制的研究

微藻的高密度培养研究

教学工作

担任本科生课程《生物化学》和《分子生物学》

担任研究生课程《高等生物工程》

承担的课题:

高密度发酵高山被孢霉生产微生物来源花生四烯酸（ARA）（厦门市科技计划项目），2014.11-2017.12
应用蛋白质组学技术解析裂殖壶菌产DHA的氮源调控分子机制（福建省基金），2013.01-2015.12；
利用基因敲除技术结合蛋白质组学分析裂殖壶菌产DHA的氮源调控分子机制（国家自然科学基金），2013.01-2015.12；
海洋微藻生产生物活性虾青素关键技术研究和示范应用（厦门市海洋与渔业局），2012.01-2012.12，；
重金属污染下互花米草根际与内生菌的群构特征和细菌效应（联合申报国家基金），2011.01-2013.12.
应用蛋白质组学技术解析虾青素引起的免疫调节分子机制（国家自然科学基金），第一参与人，2011.01-2013.12；
微藻提取DHA的技术开发（福建省科技厅重大专项）第四参与人，2010.09-2013.07.

近期主要代表论著:

1. Xueping Ling*, Hao Zhou, Qinghua Yang, Shengyang Yu, Jun Li, Zhipeng Li, Ning He, Cuixue Chen, Yinghua Lu*. Functions of enyolreductase (ER) domains of PKS cluster in lipid synthesis and enhancement of PUFAs accumulation in Schizochytrium limacinum SR21 using triclosan as a regulator of ER, Microorganisms, 2020, 8:300.

2. Di Pan, Biling Tang, Huipeng Liu, Zhenglong Li, Rongrong Ma, Yajuan Peng, Xuee Wu, Liming Che, Ning He, Xueping Ling*, Yuanpeng Wang*. Effect of high hydrostatic pressure (HHP) processing on immunoreactivity and spatial structure of peanut major allergen Ara h 1, Food and Bioprocess Technology, 2020, 13:132-144.

3. Weide Xiong, Weiyi Luo, Xueliang Zhang, Xueshan Pan, Xianhai Zeng, Chuanyi Yao, Keju Jing, Liang Shen, Cuixue Chen, Xueping Ling*, Yinghua Lu*. High expression of toxic Streptomyces phospholipase D in Escherichia coli under salt stress and its mechanism, AIChE Journal, 2019:e16856.

4. Jun Li, Hao Zhou, Xueshan Pan, Zhipeng Li, Yinghua Lu, Ning He, Tong Meng, Chuanyi Yao, Cuixue Chen, Xueping Ling*. The role of fluconazole in the regulation of fatty acid and unsaponifiable matter biosynthesis in Schizochytrium sp. MYA 1381, BMC Microbiology, 2019, 19: 256.

5. Zhipeng Li, Xueping Ling, Hao Zhou, Tong Meng, Jinjin Zeng, Wei Hang, Yanyan Shi, Ning He*. Screening chemical modulators of benzoic acid derivatives to improve lipid accumulation in Schizochytrium limacinum SR21 with metabolomics analysis, Biotechnology for Biofuels, 2019, 12:209.

6. Baobei Wang^#, Xueshan Pan^#, Jing Jia, Weide Xiong, Emmanuel Manirafasha, Xueping Ling*, Yinghua Lu*. Strategy and regulatory mechanisms of glutamate feeding to enhance astaxanthin yield in Xanthophyllomyces dendrorhous. Enzyme and Microbial Technology, 2019, 125: 45-52.

7. Zhipeng Li, Xi Chen, Jun Li, Tong Meng, Lingwei Wang, Zhen Chen, Yanyan Shi, Xueping Ling*, Weiang Luo, Dafeng Liang, Yinghua Lu, Qingbiao Li, Ning He*, Functions of PKS genes in lipid synthesis of Schizochytrium sp. by gene disruption and metabolomics analysis. Marine Biotechnology, 2018, 20(6), 792-802.

8. Xueshan Pan, Baobei Wang, Henri G. Gerken, Yinghua Lu*, Xueping Ling*. Proteomic analysis of astaxanthin biosynthesis in Xanthophyllomyces dendrorhous in response to low carbon levels. Bioprocess and Biosystems Engineering, 2017, 40:1091-1100.

9. Xueping Ling, Siyu Zeng, Cuixue Chen, Xiaoting Liu, Yinghua Lu*. Enhanced arachidonic acid production using a bioreactor culture of Mortierella alpina with a combined organic nitrogen source. Bioresoures and Bioprocessing, 2016, 3:43.

10. Xueping Ling*, Jing Guo,Chuqiang Zheng, Chiming Ye, Yinghua Lu, Xueshan Pan, Zhengqi Chen, I-Son Ng*. Simple, effective protein extraction method and proteomics analysis from polyunsaturated fatty acids-producing micro-organisms. Bioprocess and Biosystems Engineering, 2015, 38(12): 2331-2341.

11. Xueping Ling, Jing Guo, Xiaoting Liu, Xia Zhang, Nan Wang, Yinghua Lu, I-Son Ng*. Impact of carbon and nitrogen feeding strategy on high production of biomass and docosahexaenoic acid (DHA) by Schizochytrium sp. LU310. Bioresource Technology, 2015,184: 139-147.

12. I-Son Ng*, Xiaoqin Chi, Xiaomin Wu, Ziwei Bao, Yinghua Lu, Jo-Shu Chang, Xueping Ling*. Cloning and expression of Cel8A from Klebsiella pneumoniae in Escherichia coli and comparison to cel gene of Cellulomonas uda. Biochemical Engineering Journal, 2013, 78: 53-58.

13. Xueping Ling, Yinghua Lu, Heqing Huang*. Differential protein profile in Zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Environmental Science and Pollution Research, 2012, 19(9): 3925-3941.

14. Xueping Ling, Yiheng Zhang, Yinghua Lu, Heqing Huang*. Superoxide dismutase, catalase and acetylcholinesterase: biomarkers for the joint effects of cadmium, zinc and methyl parathion contamination in water. Environmental Technology, 2011, 32(13): 1463-1470.