成员介绍

卢英华

     特聘教授
     博士生导师
     电话:0592-2186038
     Email:ylu@xmu.edu.cn
    

个人简历

1988.09-1992.07 北京工商大学,学士学位

1992.09-1995.03 浙江大学化工系,硕士学位

1998.05-2002.08 德国比勒菲尔德大学(University of Bielefeld),博士学位

1995.04-1998.03 厦门大学化学化工学院化工系,讲师

2002.10-2007.07 厦门大学化学化工学院化学工程与生物工程系,副教授

2004.09-2005.10 四川省遂宁市人民政府副秘书长

2007.08-2008.06 厦门大学化学化工学院化学工程与生物工程系,教授

2008.06-2009.12 厦门大学化学化工学院化学工程与生物工程,教授,系主任

2009.12-2013.01 厦门大学化学化工学院,教授,副院长

2013.01-2018.12 厦门大学资产经营有限公司总经理、厦门大学产业技术研究院院长、厦门大学国家大学科 技园董事长

2018.12-至今  厦门大学化学化工学院,特聘教授 

研究方向

从事微生物育种、基因工程、微生物培养、生物发酵、以及生物物质分离纯化等方面的研究工作。 

教学工作

1. 本科课程:基因工程,生物分离工程,学科入门指导,化工/生工前沿讲座

2. 研究生课程:高等生物分离工程

承担的课题:

  1. 磷脂酰丝氨酸原料工艺技术及产业化,技术开发,2021.08至2023.08。

  2. 脂肪酶催化合成几种重要食品添加剂及微生物合成神经酸等重要营养强化剂技术开发,技术开发, 2020.06.01-2025.05.31。

  3. 徐州天裕南强能化新材料工业研究院有限公司—厦门大学化学化工学院科技创新与孵化中心,共建平台,2020-010-01至 2024-12-31。

  4. 人工晶状体材料的合成,厦门晶华视康医疗器械有限公司,技术开发, 2020.04.01-2021.06.30。

  5. 厦门大学化学化工学院-海斯福联合实验室,共建平台,2019.08.28-2022.08.28。

  6. 菌种和工艺改造提质及产品化技术,合作开发,2019.11.01-2024.11.01。

  7. 面向分子筛分的新型多孔骨架材料及复合膜应用基础研究,国家自然科学基金重点项目, 2018.01-2022.12。

  8. 微藻破壁离心细胞碎片中磷脂的提取技术的研究,“十三五”厦门市海洋经济创新发展示范项目,2016.10-2019.10。 

  9. 纳他霉素发酵工艺开发,黑龙江格林赫斯生物科技有限公司,技术开发, 2014.09-2015.12。

  10. 高密度培养裂殖壶菌发酵生产DHA,临沂宝力佳食品有限公司,科技转让, 2015.4.20-2020.04.19。

  11. 庆大霉素高单位低杂质菌株筛选及工艺开发,福建省福抗药业股份有限公司,技术开发, 2015.01-2017.01。

  12. 高产色氨酸菌株构建与转让,德国Degussa公司,技术转让, 2013.12-2014.12。

  13. 厦门大学-金达威食品营养工程技术研究中心,厦门金达威集团,2013.6-2017.12,中心主任。

  14. 豆粕发酵技术开发,校企合作,四川渴望生物科技有限公司,2013.01-2017.12。

  15. 海洋微生物合成虾青素的关键集成技术研究与集约化生产示范,海洋公益性行业科研专项经费,2012.1-2015.12。

  16. 厦门大学-蓝恒达精细化工联合实验室,江西蓝恒达化工有限公司,2011.11-2021.11,中心主任。

  17. 应用蛋白质组学技术解析虾青素引起的免疫调节分子机制,国家自然科学基金,2011.01-2013.12。

  18. 亚麻酸发酵生产技术开发,厦门金达威集团股份有限公司,技术转让,2011.09-2016.09。

  19. 红法夫酵母发酵生产虾青素,校企合作,厦门汇盛生物有限公司,2010-2013。

  20. 微藻提取DHA的技术开发,福建省科技重大专项, 2010.09.01-2013.07.31。

  21. 多不饱和脂肪酸系列生产技术开发,技术开发,浙江亿叠生物科技有限公司,2010.5.10-2020.5。

  22. 天津滨海新区轻纺工业园区轻纺与印染水处理方案,天津滨海新区环境保护与市容管理局,起止时间:2010.02.04-2015.02.03。

  23. 玫瑰孢链霉菌发酵生产达托霉素, 福建发展和改革委员会,起止时间:2009.9-2012.12。

  24. 豆粕发酵技术开发,校企合作,四川渴望生物科技有限公司,2009.01.01-2010.01.01。

  25. 发酵法生产DHA,科技转让,浙江海正制药集团,2009.01-2010.06。

  26. 发酵法生产纳他霉素,科技转让,江苏海华科技有限公司,起止时间:2008.09.10-2013.09.09。

近期主要代表论著:

1.Rongrong Ma, Huipeng Liu, Yuanhong Li, Bior James Akoi Atem, Xueping Ling*, Ning He, Liming Che, Xuee Wu, Yuanpeng Wang, Yinghua Lu*. Effects of high hydrostatic pressure treatment: characterization of eel (Anguilla japonica) surimi, structure and angiotensin-converting enzyme inhibitory activity of myofibrillar protein, Food and Bioprocess Technology, 2021, 14: 1631-1639. 

2.Wenyao Shao *, Ying Lin and Yinghua Lu *. Study on the Extraction Technology of Candida antarctica Lipase B by Foam Separation, Processes, 2021, 9, 14. 

3.Lufang Shen, Quanling Xie*, Zhuan Hong, Chenpu Wu, Tong Yu, Hua Fang, Ying Xiong, Guoliang Zhang, Yinghua Lu*,  Wenyao Shao*.Facile Strategy to Construct High-Performance Nanofiltration Membranes by Synergy of Graphene Oxide and Polyvinyl Alcohol .Industrial & Engineering Chemistry Research. 2020, 59, 42, 19001–19011. 

4.Xueshan Pan, Baobei Wang, Ran Duan, Jing Jia, Jun Li, Weide Xiong, Xueping Ling*, Cuixue Chen, Xiaohong Huang, Guoliang Zhang, Yinghua Lu*. Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles, Microbial Biotechnology, 2020, 13(5):1446–1460. 

5.Chenpu Wu, Quanling Xie*, Zhuan Hong, Lufang shen, Tong Yu, Honghui Guo, Ying Xiong, Guoliang Zhang, Yinghua Lu*, Wenyao Shao*,Thin-film nanocomposite nanofiltration membrane with enhanced desalination and antifouling performance via incorporating L-aspartic acid functionalized graphene quantum dots.Desalination,2020, 498:114811. 

6.Theophile Murwanashyaka, Liang Shen*, Zheng Yang, Jo-Shu Chang, Emmanuel Manirafasha, Theoneste Ndikubwimana, Cuixue Chen, Yinghua Lu*. Kinetic modelling of heterotrophic microalgae culture in wastewater: Storage molecule generation and pollutants mitigation. Biochemical Engineering Journal, 2020, 157: 107523. 

7. Xueping Ling*, Hao Zhou, Qinghua Yang, Shengyang Yu, Jun Li, Zhipeng Li, Ning He, Cuixue Chen, Yinghua Lu*. Functions of enyolreductase (ER) domains of PKS cluster in lipid synthesis and enhancement of PUFAs accumulation in Schizochytrium limacinum SR21 using triclosan as a regulator of ER, Microorganisms, 2020, 8:300.

8.Weide Xiong, Weiyi Luo, Xueliang Zhang, Xueshan Pan, Xianhai Zeng, Chuanyi Yao, Keju Jing, Liang Shen, Cuixue Chen, Xueping Ling*, Yinghua Lu*. High expression of toxic Streptomyces phospholipase D in Escherichia coli under salt stress and its mechanism, AIChE Journal, 2019, 66:e16856. 

9.Liang Shen*, Shaila Akter Saky , Zheng Yang , Shih-Hsin Ho, Cuixue Chen, Lei Qin, Guoliang Zhang, Yuanpeng Wang, Yinghua Lu*. The critical utilization of active heterotrophic microalgae for bioremoval of Cr(VI) in organics co-contaminated wastewater. Chemosphere, 2019, 228:536-544. 

10.Baobei Wang, Xueshan Pan, Jing Jia, Weide Xiong, Emmanuel Manirafasha, Xueping Ling*, Yinghua Lu*. Strategy and regulatory mechanisms of glutamate feeding to enhance astaxanthin yield in Xanthophyllomyces dendrorhous. Enzyme and Microbial Technology, 2019, 125: 45-52. 

11.Hanjun Ma, Quanling Xie, Chenpu Wu, Lufang Shen, Zhuan Hong, Guoliang Zhang, Yinghua Lu*, Wenyao Shao*. A facile approach to enhance performance of PVDF-matrix nanocomposite membrane via manipulating migration behavior of graphene oxide. Journal of Membrane Science. 2019, 590: 117268.

12.Wenyao Shao, Chenran Liu, Hanjun Ma, Zhuan Hong, Quanling Xie*, Yinghua Lu*. Fabrication of pH-sensitive thin-film nanocomposite nanofiltration membranes with enhanced performance by incorporating aminefunctionalized graphene oxide. Applied surface science. 2019, 487:1209-1221.

13.Weide Xiong, Xianhai Zeng, Shih-Hsin Ho, Xueping Ling, Liang Shen, Chuanyi Yao*, Yinghua Lu*. Strategies for achieving high-level and stable production of toxic Streptomyces phospholipase D in Escherichia coli. Journal of Chemical Technology and Biotechnology, 2019,94(4):1220-1229. 

14.Emmanuel Manirafasha,Theophile Murwanashyaka, Theoneste Ndikubwimana, Nur Rashid Ahmed, Jingyi Liu, Yinghua Lu⁎, Xianhai Zeng, Xueping Ling, Keju Jing⁎. Enhancement of cell growth and phycocyanin production in Arthrospira (Spirulina) platensis by metabolic stress and nitrate fed-batch. Bioresource Technology,2018, 255:293-301.

15.Liang Shen, Jean Damascene Ndayambaje, Theophile Murwanashyaka, Wenqian Cui, Emmanuel Manirafasha, Cuixue Chen, Yuanpeng Wang, Yinghua Lu*. Assessment upon heterotrophic microalgae screened from wastewater microbiota for concurrent pollutants removal and biofuel production. Bioresource Technology, 2017, 245: 386-393.

16.Theophile Murwanashyaka, Liang Shen*, Jean Damascene Ndayambaje, Yuanpeng Wang, Ning He, Yinghua Lu*. Kinetic and transcriptional exploration of Chlorella sorokiniana in heterotrophic cultivation for nutrients removal from wastewaters. Algal Research, 2017, 24, Part B, 467-476.

17.Baobei Wang, Yang Pu, Youping Xie, Zijian Cai, Qiaoying Zheng, and Yinghua Lu*. Combined Adsorption and Ion Exchange of D-Glyceric Acid Using a Strong Basic Resin: Equilibrium, Kinetics, and Thermodynamics [J]. Chemical and Biochemical Engineering Quarterly. 2017, 31(4): 471-478.

18.Ruijuan Ma, Yan Li*, Yinghua Lu*, Sequencing and characterization of novel PII signaling protein gene in microalga Haematococcus pluvialis. Marine Drugs, 2017, 15(10): 304. 

19.Xueshan Pan, Baobei Wang, Henri G. Gerken, Yinghua Lu*, Xueping Ling*. Proteomic analysis of astaxanthin biosynthesis in Xanthophyllomyces dendrorhous in response to low carbon levels. DOI 10.1007/s00449-017-1771-5. Bioprocess and Biosystem Engineering. 2017.05.

20.Emmanuel Manirafasha, Theophile Murwanashyaka, Theoneste Ndikubwimana, Qian Yue, Xianhai Zeng, Yinghua Lu*, Keju Jing*. Ammonium chloride: a novel effective and inexpensive salt solution for phycocyanin extraction from Arthrospira (Spirulina) platensis. Journal of Applied Phycology, 2017,29 (3): 1261–1270. 

21.Theoneste Ndikubwimana, Xianhai Zeng*, Theophile Murwanashyaka, Emmanuel Manirafasha, Ning He, Wenyao Shao, Yinghua Lu*. Harvesting of freshwater microalgae with microbial bioflocculant: A pilot-scale study, Biotechnology for Biofuels, 2016,9(47). 

22.Youping Xie, Shih-Hsin Ho, Ching-Nen Nathan Chen, Chun-Yen Chen, Keju Jing , I-Son Ng, Jianfeng Chen, Jo-Shu Chang*, Yinghua Lu*.Disruption of thermo-tolerant Desmodesmus sp. F51 in high pressure homogenization as a prelude to carotenoids extraction. Biochemical Engineering Journal, 2016,109:243-251.

23.Theoneste Ndikubwimana, Jingyu Chang, Zongyuan Xiao, Wenyao Shao, Xianhai Zeng*, I-Son Ng, Yinghua Lu*. Flotation: A promising microalgae harvesting and dewatering technology for biofuels production, Biotechnology Journal, 2016,11(3).

24.Theoneste Ndikubwimanaa, Xianhai Zeng∗, Ning He, Zongyuan Xiao,Youping Xie, Jo-Shu Chang, Lu Lin,Yinghua Lu∗.Microalgae biomass harvesting by bioflocculation-interpretation by classical DLVO theory. Biochemical Engineering Journal.2015,101:160-167.

25.Chao zheng, Xianhai Zeng, Michael K. Danquah, Yinghua Lu*. NaCS-PDMDAAC Immobilized Cultivation of Recombinant Dictyostelium discoideum for Soluble Human Fas Ligand Production. Biotechnology Progress. 2015, 31(2): 424-430. 

26.Baobei Wang, Zhen Zhang, Qiang Hu, Milton Sommerfeld, Yinghua Lu*, Danxiang Han*. Cellular capacities for high-light acclimation and changing lipid profiles across life cycle stages of the green alga Haematococcus pluvialis. PLOS ONE. 2014, 9(9): e106679. 

27.Youping Xie, Hang Li, Xiaowei Wang, I-Son Ng, Yinghua Lu*, Keju Jing*. Kinetic simulating of Cr(VI) removal by the waste Chlorella vulgaris biomass. Journal of the Taiwan Institute of Chemical Engineers. 2014, 45: 1773-1782. 

28.Youping Xie, Shih-Hsin Ho, Chun-Yen Chen, Ching-Nen Nathan Chen, Chen-Chun Liu, I-Son Ng, Keju Jing, Sheng-Chung Yang, Chi-Hui Chen, Jo-Shu Chang*, Yinghua Lu*. Simultaneous enhancement of CO2 fixation and lutein production with thermo-tolerant Desmodesmus sp. F51 using a repeated fed-batch cultivation strategy. Biochemical Engineering Journal. 2014 , 86: 33-40. 

29.Liang Shen, Xia Yuan. Weihuang Shen, Ning He, Yuanpeng Wang, Haoliang Lu, Yinghua Lu*. Positive impact of biofilm on reducing the permeation of ampicillin through membrane for membrane bioreactor. Chemosphere, 2014, 97: 34-39. 

30.Xianhai Zeng, Chong Xun Quek, Michael K. Danquah, Meng Wai Woo, Yinghua Lu*, Xiao Dong Chen, Falling film evaporation characteristics of microalgae suspension for biofuels production, Applied Thermal Engineering. 2014, 62(2): 341-350.

31.Youping Xie, Shih-Hsin Ho, Ching-Nen Nathan Chen, Chun-Yen Chen, I-Son Ng, Ke-Ju Jing, Jo-Shu Chang, Yinghua Lu* . Phototrophic cultivation of a thermo-tolerant Desmodesmus sp. for lutein production: Effects of nitrate concentration, light intensity and fed-batch operation. Bioresource Technology . 2013, 144: 435-444. 

32.Xianhai Zeng, Michael K. Danquah,∗ Ravichandra Potumarthi, Jia Cao,Xiao Dong Chen and Yinghua Lu∗. Characterization of sodium cellulose sulphate/poly-dimethyl-diallyl-ammonium chloride biological capsules for immobilized cultivation of microalgae. Journal of Chemical Technology and Biotechnology, 2013, 88: 599-605. 

33.Xianhai Zeng, Michael K. Danquah, Roald Halim, Xiaodong Chen, Yinghua Lu*. Comparative physicochemical analysis of suspended and immobilized cultivation Chlorella sp. Journal of Chemical Technology and Biotechnology, 2013.02, 88(2): 247-254. 

34.Xianhai Zeng, Michael K. Danquah, Keju Jing, Meng Wai Woo, Xiao Dong Chen, Youping Xie, Yinghua Lu*.Solubility properties and diffusional extraction behaviour of natamycin from Streptomyces gilvosporeus biomass, Biotechnology Progress, 2013.01, 29(1):109-115. 

35.Liang Shen, Yinghua Lu*, Yu Liu. Mathematical modeling of biofilm-covered granular activated carbon: a review, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY . 2012.11, 87(11): 1513-1520. 

36.Xianhai Zeng, Michael K. Danquah, Chong Xun Quek, Meng Wai Woo, Xiaodong Chen, Yinghua Lu*. Pool boiling characteristics of microalgae suspension for biofuels production. Applied Thermal Engineering. 2013.01, 50(1):1369-1375. 

37.Xianhai Zeng, Michael K. Danquah, Chao Zheng, Ravichandra Potumarthi, Xiaodong Chen, Yinghua Lu*. NaCS–PDMDAAC immobilized autotrophic cultivation of Chlorella sp. for wastewater nitrogen and phosphate removal. Chemical Engineering Journal, 2012, 187: 185-192. 

38.Xianhai Zeng, Michael K. Danquah, Shiduo Zhang, Xia Zhang, Mengyang Wu, Xiaodong Chen , I-Son Ng, Keju Jing, Yinghua Lu*. Autotrophic cultivation of Spirulina platensis for CO2 fixation and phycocyanin production. Chemical Engineering Journal, 2012, 183: 192-197.

39.Zhen Luo, Zhinan Xu, Shanling Zhuo, Keju Jing, Yinghua Lu*. Production, purification and cytotoxity of soluble human Fas ligand expressed by Escherichia coli and Dictyostelium discoideum. Biochemical Engineering Journal, 2012, 62: 86-91. 

授权专利:

 1.    卢英华,熊维德,曾宪海,姚传义,沈亮,陈翠雪. 一种重组大肠杆菌生产磷脂酶D的方法,ZL201810843255.2,授权时间:2020.11.05.

2.     卢英华,熊维德,曾宪海,姚传义,沈亮,陈翠雪. 一种分离纯化大肠杆菌重组磷脂酶D的方法,ZL 201810846519.X,授权时间:2020.10.27.

3.     卢英华,何彩云,姚传义,林旺锦. 固定化脂肪酶的制备方法. 中国发明专利,ZL201510058160.6,授权时间:2017.05.03.

4.     卢英华, 陈慧敏, 蒲洋, 王宝贝, 敬科举, 陈翠雪. 一种用于生产甘油酸的热带醋杆菌的驯化方法. 中国发明专利, ZL201410553955.X,授权时间:2016.10.26  

5.     卢英华, 蒲洋, 陈慧敏, 王宝贝, 敬科举, 陈翠雪. 一种热带醋杆菌全细胞催化生产甘油酸的方法. 中国发明专利, ZL201410552593.2,授权时间:2017.11.07.

6.     卢英华,海璇隽,凌雪萍,姚传义,吴意珣,陈翠雪,王丽娟. 一种红法夫酵母菌中虾青素分离纯化的方法, 中国发明专利, ZL201410298119.1,授权时间:2016.06.15.

7.     卢英华,曾思钰,凌雪萍,敬科举,吴意珣,陈翠雪。一种花生四烯酸的制备方法,中国发明专利,  ZL201310416765.9,授权时间: 2015.08.19.

8.     敬科举, 郭立, 卢英华. 一种发酵液中纳他霉素的提取纯化方法,中国发明专利, ZL 201410006599.X,授权时间:2016.05.18.

9.     卢英华,王丽娟,沈亮,海璇隽,吴意珣,凌雪萍,姚传义,敬科举. 裂殖壶藻胞外多糖的分离纯化方法,中国发明专利,  ZL201310167325.4,授权时间:2015.08.05.

10.  卢英华, 王宝贝, 敬科举, 凌雪萍. 一种虾青素生产菌株及其诱变筛选方法与应用.中国发明专利, ZL201010150422.9, 授权时间: 2013.09.18.

11.  敬科举, 卢英华, 郝小兵, 曾宪海. 发酵罐底物流加生产纳他霉素的方法. 中国发明专利, ZL201010227917.7, 授权时间: 2013.01.02.

12.  卢英华, 倪洁, 周林, 陈丽珠, 敬科举, 乔兴忠. 一种全合成培养基及其制备方法和用于培养裂殖壶菌的方法. 中国发明专利, ZL201010150460.4, 授权时间: 2012.07.25.

13.卢英华, 曾宪海, 敬科举, 姚传义, 凌雪萍. 核糖体抗性诱变选育万古霉素生产菌株及其应用. 中国发明专利, ZL200910112190.5, 授权时间: 2011.08.31.

14.卢英华, 郑超, 何宁, 敬科举, 姚传义. 纤维素硫酸钠的制备方法.中国发明专利, ZL101550194, 授权时间: 2011.08.10.

15.何宁, 卢英华, 邓旭, 程志敬, 王明轩, 李清彪, 敬科举. 从重组大肠杆菌 XM-LU 制备内切-β-1,3-1,4-葡聚糖酶的方法.中国发明专利, ZL200810070684.7, 授权时间: 2010.01.20.

16.卢英华. 一种豆粕发酵用的高效发酵剂以及应用该发酵剂进行豆粕发酵的工艺.中国发明专利, ZL20091011504.X, 授权时间: 2009.09.16.

17.卢英华, 王颖, 何宁, 徐志南, 陈翠雪, 凌雪萍. 盘基网柄菌的半合成培养基及其制备方法.中国发明专利, ZL200710008500.X, 授权时间: 2009.01.21.

获奖情况:

1.     2021年获中国产学研合作创新奖。

2.     2020年牵头组建的“功能性生物活性物质研究与开发”团队入选福建省高等学校科技创新团队。

3.     2020年获厦门市“双百计划”领军型创业人才称号。

4.     2020年获厦门大学“田邵武学科交叉奖(一等奖)”

5.     2018年获第七届厦门市专利奖二等奖。

6.     2018年获厦门大学化学化工学院园丁奖教金。

7.     2016年获第六届中国侨届贡献(创新成果)奖。

8.     2014年获福建省科学技术进步奖二等奖。

9.     2014年获得厦门大学田昭武学科交叉奖

10.  2014年指导学生获创青春福建省大学生创业大赛之第八届挑战杯福建省大学生创业计划竞赛金奖。

11.  2013年获得厦门大学创业创新鼓励基金二等奖。

12.  2012年指导学生获得第八届挑战杯中国大学生创业计划竞赛金奖。

13.  2012年指导学生获得第七届“挑战杯”福建省大学生创业计划竞争中获金奖。

14.  2011年获得第十届“挑战杯”天翼福建省大学生课外学术科技作品竞赛“优秀指导教师”称号;

15.  2011年指导学生获得第十届“挑战杯”天翼福建省大学生课外学术科技作品竞赛特等奖。

16.  2011年指导学生获得第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖。

17.  2011年获得厦门大学“南强奖”。

 

厦门大学化学工程与生物工程系
Email: chem.eng@xmu.edu.cn Tel: +86 (0)592 2183751
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